Like Mike is about a trio of kids who live in an orphanage. The trio is played by Lil' Bow Wow, Brenda Song, and Jonathan Lipnicki. They are best friends and they enjoy playing basketball and watching NBA games on television. They are taken by Stan Bittleman, the greedy orphanage director (played by Crispin Glover) to sell chocolates after each of a fictional Los Angeles Knights NBA franchise's home games.

One night after a game, Calvin Cambridge (Lil' Bow Wow) meets the team's coach who is impressed by Calvin's knowledge of basketball and honesty about the chocolates he sells, and offers Calvin...