I don't think she will show up in the anime, since she was introduced in FireRed and LeafGreen. That was in 2004 ( North America ) I believe, so if she was to make an appearance why wait so many years? As much as I would love for her to show up, it's unlikely she will.
Well,the Kanto region has passed by,so that puts me in doubt,but they could do a side story with Red/Leaf/Blue & the Kanto gym leaders and the story in general,but right now I'm in doubt,but I think it would be a great addition/idea!