Well, almost all of the Protagonists from The Melancholy of Haruhi Suzumiya![Except Kyon ofcourse!(FYI, Kyon's the one holding the board written SOS!)]
Yuki (the Purple ash haired one)- is an alien!
Mikuru (the orange-brown hair)-Is a time traveller
Itsuki (the other brown haired boy)-is an Esper
and Haruhi (the one with the Ribbon)- is supposedly, God!
Here's some non human anime characters:
Ddraig from High School DxD {Picture}
Pantherlily from Fairy Tail
Capricorn from Fairy Tail
Eight Tales Gyuki from Naruto Shippuden
Nine Tails Kurama from Naruto/Shippuden
Acnologia from Fairy Tail